NHMRC Research Fellowship 2008 - Bathgate

Grant number: 509011 | Funding period: 2008 - 2012

Completed

Abstract

I am a molecular endocrinologist determining the mechanisms by which relaxin family peptides bind to and activate their receptors and induce their biological effects. I use the information gained from these studies to further our understanding of the phys

Related publications (7)

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Relaxin family peptides and their receptors

RAD Bathgate, ML Halls, ET van der Westhuizen, GE Callander, M Kocan, RJ Summers

2013-01-01

There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male re..

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Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin

LJ Chan, KJ Rosengren, SL Layfield, RAD Bathgate, F Separovic, CS Samuel, MA Hossain, JD Wade

2012-11-30

Human gene-2 (H2) relaxin is currently in Phase III clinical trials for the treatment of acute heart failure. It is a 53-amino aci..

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Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: The additional involvement of iNOS

BSM Chow, EGY Chew, C Zhao, RAD Bathgate, TD Hewitson, CS Samuel

2012-08-22

The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-β1/Smad2 axis,..

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Silencing relaxin-3 in nucleus incertus of adult rodents: A viral vector-based approach to investigate neuropeptide function

GE Callander, S Ma, DE Ganella, VC Wimmer, AL Gundlach, WG Thomas, RAD Bathgate

2012-08-02

Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the n..

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Prevention of bleomycin-induced pulmonary fibrosis by a novel antifibrotic peptide with relaxin-like activity

A Pini, R Shemesh, CS Samuel, RAD Bathgate, A Zauberman, C Hermesh, A Wool, D Bani, G Rotman

2010-12-01

Pulmonary fibrosis is a progressive and lethal lung disease characterized by accumulation of extracellular matrix and loss of pulm..

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Development and optimization of MicroRNA against relaxin-3

GE Callander, WG Thomas, RAD Bathgate

2009-01-01

Recent in vivo studies suggest a role for relaxin-3 in feeding and stress. To further elucidate the function of relaxin-3 in the c..

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Resolving the unconventional mechanisms underlying RXFP1 and RXFP2 receptor function

BJ Hartley, DJ Scott, GE Callander, TN Wilkinson, DE Ganella, CK Kong, S Layfield, T Ferraro, EJ Petrie, RAD Bathgate

2009-01-01

The receptors for relaxin and insulin-like peptide 3 (INSL3) are now well-characterized as the relaxin family peptide (RXFP) recep..

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